Here's a Tumblr blog of Jimmy McNulty smirking. metafilter discussion about whether those are actually smirks. What is a 'smirk' anyway? A self-centred smile: sounds like McNulty.
Here's a horrid video about trypophobia. Sufferers can't bear to look at little holes in things. My guess is it's an exaggeration of a rational evolved avoidance of parasites. I kind of know what they are getting at, but grills and bubbles don't freak me out. Little things wiggling out of little holes - now that's nasty.